Name | 4-Acetamidobenzoic acid |
Synonyms | PAAB PAABA acedoben Acedoben Acetylated PABA 4-Carboxyacetanilide 4'-Carboxyacetanilide p-Acetamidobenzoic acid 4-(acetylamino)benzoate 4-Acetamidobenzoic acid P-Acetamido Benzoic acid p-Acetylamino benzoic acid 4-(acetylamino)-benzoicaci Benzoic acid, p-acetamido- Benzoic acid, 4-acetamido- 4-(acetylamino)benzoic acid Benzoic acid, 4-(acetylamino)- |
CAS | 556-08-1 |
EINECS | 209-114-7 |
InChI | InChI=1/C9H9NO3/c1-6(11)10-8-4-2-7(3-5-8)9(12)13/h2-5H,1H3,(H,10,11)(H,12,13)/p-1 |
Molecular Formula | C9H9NO3 |
Molar Mass | 179.17 |
Density | 1.2822 (rough estimate) |
Melting Point | 259-262°C (dec.)(lit.) |
Boling Point | 311.69°C (rough estimate) |
Flash Point | 219.7°C |
Water Solubility | <0.1 g/100 mL at 21 ºC |
Solubility | DMSO (Slightly), Methanol (Slightly) |
Vapor Presure | 1.66E-08mmHg at 25°C |
Appearance | White crystal |
Color | Off-white to slightly beige |
BRN | 390602 |
pKa | pK1: 4.28 (25°C) |
Storage Condition | Sealed in dry,Room Temperature |
Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
Refractive Index | 1.5600 (estimate) |
MDL | MFCD00002534 |
Physical and Chemical Properties | White patchy crystals. Melting point 256.5 °c. Soluble in ethanol, insoluble in water and ether. |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | 24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |
TSCA | Yes |
HS Code | 29242995 |
NIST chemical information | information provided by: webbook.nist.gov (external link) |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
Use | for organic synthesis. is an acetylated derivative of P-aminobenzoic acid and a metabolite of the anesthetic benzocaine. |
production method | Method 1: p-aminobenzoic acid is used as a starting material and is obtained by acetylation. P-aminobenzoic acid was dissolved in ethyl acetate, acetic anhydride was added with stirring and the temperature was raised to 70 °c. Then it was cooled, filtered, washed twice with water, and then crystallized with ethanol to obtain a finished product. Method 2: with P-toluidine as raw material, it was obtained by acetylation and oxidation. Acetylated with acetic anhydride as raw material, oxidation with potassium permanganate, oxidation temperature of 60-70 deg C. |